window.figureViewer={doi:'10.1177/1753193419882851',path:'/na101/home/literatum/publisher/sage/journals/content/jhsc/2020/jhsc_45_3/1753193419882851/20200212',figures:[{i:'table1-1753193419882851',type:'table-wrap',g:[{m:'10.1177_1753193419882851-table1.gif',l:'10.1177_1753193419882851-table1.jpeg',size:'616 KB'}]} There has been a much quoted concept of DD being labeled as the “Viking“ or “Nordic“ disease. The earliest reference that we found in the medical literature to the condition that ultimately came to be known as Dupuytren’s Disease was a report by Felix Plater in the 17 th century. Add to this the known prehistoric cases (like the Egyptian mummy) that are clearly … By Lauren Clark PUBLISHED: 13:12, Mon, May 8, 2017 Lean Library can solve it. Le travail manuel n’est pas responsable de la maladie de Dupuytren. Selon ce spécialiste de l’appareillage de la main et du membre supérieur, “le doigt à la. The authors declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article. Exceptionnelle chez les Asiatiques (1 seul cas), les Africains (à peine 8 cas répertoriés) et les Indiens (10 cas décrits) , la maladie de Dupuytren survient seulement chez les sujets blancs, européens du nord (Islande, Scandinavie, Russie, Angleterre) et chez leurs descendants, en particulier dans les pays d'émigration britannique (Canada, États-Unis, Australie). The authors disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: DF was supported by an Intermediate Clinical Fellowship from the Wellcome Trust [097152/Z/11/Z]. La maladie de Dupuytren est une maladie d'origine inconnue qui touche des tissus (les aponévroses) dont le rôle est de protéger les muscles, les nerfs et les vaisseaux. If DD were of Norse origin, we would expect that the total FST of our disease-associated SNPs would be higher than randomly generated groups of SNPs. mémoire de la … This product could help you, Accessing resources off campus can be a challenge. View or download all the content the society has access to. Toutefois, aucun lien de cause à effet n'a été démontré entre ces deux maladies. To date, genome-wide association studies (GWAS) have revealed 26 loci predisposing to DD (Dolmans et al., 2011; Ng et al., 2017). Dupuytren's disease is currently called a Viking disease on the assumption that the disease was spread to Europe and the British Isles during the Viking Age of the 9th to the 13th centuries. La maladie de Dupuytren est une maladie génétique. En 1831, le baron Guillaume Dupuytren fut le premier à décrire en détail cette affection caractérisée par des contractures digitales, et le premier aussi à les traiter chirurgicalement. ,{i:'fig1-1753193419882851',type:'fig',g:[{m:'10.1177_1753193419882851-fig1.gif',l:'10.1177_1753193419882851-fig1.jpeg',size:'207 KB'}]} Written informed consent was obtained from all subjects before the study. (a) Dupuytren’s genetic risk score is not significantly different from random in a haplotype-based test for population structure. La maladie de Dupuytren est une sorte de pathologie qui se caractérise par la rétraction progressive d’un ou plusieurs ou doigts de la main. Tradition has it that the disease originated with the Vikings, who spread it throughout Northern Europe and beyond as they traveled and intermarried. View or download all content the institution has subscribed to. Cet épaississement s’accompagne d’une rétraction qui limite l’extension des doigts et peut infiltrer la peau. Finally, a GRS derived from DD-associated SNPs did not show increased geographical clustering around areas of known high Norse ancestry. Our results do not provide support for the hypothesis that DD is a ‘disease of the Vikings’. The local painting for the 21 independent Dupuytren’s GWAS hits was extracted and the frequency for which individuals with each population label shared a most recent haplotype with individuals of each other population was calculated, to form a population co-ancestry matrix for each position in the genome. La maladie de Dupuytren est une maladie d'origine inconnue qui touche des tissus (les aponévroses) dont le rôle est de protéger les muscles, les nerfs et les vaisseaux. L'héritage viking (3) : Les Vikings n’ont pas laissé que des vestiges archéologiques. Les modérateurs de ce forum sont des bénévoles et Dupuytren e.V. Members of _ can log in with their society credentials below, Journal of Hand Surgery (European Volume), Michael Ng, Daniel J Lawson, Bruce Winney, and Dominic Furniss, This article is distributed under the terms of the Creative Commons Attribution 4.0 License (. Mesures d`hygiène : tenue de base, précautions. The most commonly used measure of genetic difference between populations is Wright’s Fixation Index (FST) (Hudson et al., 1992). Is Dupuytren’s disease really a ‘disease of the Vikings’? Why Is Dupuytren's Contracture Called Viking Disease? When a genetic risk score is averaged over the 35 counties of the UK, there is no structure, even in areas with high Viking ancestry such as Orkney (Northernmost population). Les choix therapeutiques restent donc incertains comme en temoigne la multiplicite des techniques chirurgicales et des … Get the News Letter from Dupuytren Research Group, Information for Scientists and Clinicians, Dupuytren Research Group 2012 Research Grants. hygiène des mains. In Orkney vs Wales, the DD-associated set was on the 74th centile; in Orkney vs South East, it was on the 81st centile; and in Orkney vs Wales and South East, it was on the 92nd centile. Dupuytren disease has been referred to as a Viking or Celtic disease, but existed in Europe earlier than the Viking Age8345270 and originated much earlier in prehistory 12015711 . Within the UK there are geographical population clusters that can be separated on the basis of their inherited genetic variation (Leslie et al., 2015). L’atteinte d’autres membres de la famille, avec des formes de sévérité variable, semble indiquer une origine génétique. We used recently reported genetic association results from the British Society for Surgery of the Hand Genetics of Dupuytren’s Disease (BSSH-GODD) (Ng et al., 2017) to provide empirical evidence to investigate whether DD is associated with Norse ancestry. It is the most common inherited disease of the connective tissue and its prevalence is increasing (Bebbington and Furniss, 2015). window.figureViewer={doi:'10.1177/1753193419882851',path:'/na101/home/literatum/publisher/sage/journals/content/jhsc/2020/jhsc_45_3/1753193419882851/20200212',figures:[{i:'table1-1753193419882851',type:'table-wrap',g:[{m:'10.1177_1753193419882851-table1.gif',l:'10.1177_1753193419882851-table1.jpeg',size:'616 KB'}]} ,{i:'fig2-1753193419882851',type:'fig',g:[{m:'10.1177_1753193419882851-fig2.gif',l:'10.1177_1753193419882851-fig2.jpeg',size:'1 MB'}]} It has been suggested that DD is a ‘disease of the Vikings’ (Flatt, 2001). I have read and accept the terms and conditions, View permissions information for this article. The authors wish to acknowledge all of the individuals who participated in both studies. Maladie de Dupuytren : définition C'est une fibrose rétractile irréductible de l'aponévrose palmaire de la main avec rétraction et flexion des doigts, perception de nodules durs et épaississement de l'aponévrose palmaire moyenne. DD is a typical complex disease (Hart and Hooper, 2005). We conclude that there is no genetic evidence for a ‘Viking origin of Dupuytren’s disease’. The mean difference in total FST between cases and controls ranged between −0.06 and 0.05 (Table 2). D’autres pathologies d’altération de gènes responsables de dégradation du collagène ont été également retrouvées. La maladie de Dupuytren est caractérisée par une rétraction des doigts secondaire à une prolifération de tissu fibreux rétractile dans l’aponévrose palmaire et ses prolongements dans les doigts. RAPPEL La maladie décrite en 1831 par le Baron Guillaume Dupuytren, chirurgien de l’Hôtel-Dieu de Paris, est génétique et d’origine Viking. For the case-control analysis, the total genomic FST was calculated for each individual case or control using the formula: Second, the total FST of the DD-associated SNPs from BSSH-GODD was calculated and compared with the total FST of 10,000 randomly generated permutations of SNP groups of the same size, to generate an empirical p-value for the ‘Viking origin’ of DD-associated SNPs. La maladie de Dupuytren est d’origine inconnue. La maladie de Dupuytren atteint 216 d’entre eux, soit une prévalence de 7,1%. La maladie de Dupuytren ou contracture de Dupuytren est une fibrose rétractile de l'aponévrose palmaire (une membrane située entre les tendons fléchisseurs et la peau). (b) Orkney vs Wales; (c) Orkney vs South East; (d) Orkney vs Wales and South East. Tombe viking de Locmaria (ile de Groix), ... La première, maladie de Dupuytren (du nom du chirurgien, Le baron Guillaume Dupuytren(1777-1835) qui l’a décrite en 1831) ... entrainant des réactions du corps à l’origine de ces maladies. Pour des raisons mal connues, ces tissus deviennent épais, se pelotonnent d'abord en boule (les nodules) ce qui entraîne des plis dans la paume ou les doigts. La maladie de Dupuytren et le syndrome du canal carpien peuvent survenir chez le même patient. J'ai du mal à étirer mes doigts. The PoBI dataset consisted of a geographically diverse sample of 2039 individuals from the United Kingdom, which were then compared with 6209 individuals from across Europe to generate signals of historical demographic shifts. La maladie de Dupuytren est une maladie d’origine inconnue qui touche des tissus (les aponévroses) dont le rôle est de protéger les muscles, les nerfs et les vaisseaux. Elle est plus fréquente chez les hommes, les diabétiques ou en cas de consommation chronique d’alcool. (Fig. La maladie de Dupuytren a été décrite par le Baron Dupuytren en 1832. Please check you selected the correct society from the list and entered the user name and password you use to log in to your society website. We computed Wright’s Fixation Index between Orkney (Norse ancestry), Wales (ancient British) and South East England … This was the first time Dupuytren had been described as a “Viking disease”, something which has since been repeated over and over – and over. En règle générale, la quantité d’alcool consommée (volume, fréquence et durée) détermine le risque et la gravité des lésions hépatiques. FST for each SNP was calculated using Hudson’s estimator of FST (Hudson et al., 1992), as implemented in EIGENSOFT (https://www.hsph.harvard.edu/alkes-price/software/). Dupuytren’s disease, Morbus Dupuytren or palmar fibromatosis, sometimes also called DD, Dupuytren’s contracture, or Viking disease, is a chronic disease that produces a benign thickening of the connective tissue, or fascia, of the palm and fingers. For the permutation analysis, we first determined the SNPs to represent each of the 26 credible sets associated with DD. Elles s … The recruitment, genotyping, imputation and analysis methods for the BSSH-GODD and PoBI studies have been previously described (Leslie et al., 2015; Ng et al., 2017). Dupuytren’s disease (DD) is a disease of the palmar fascia that causes flexion contractures of the fingers (Townley et al., 2006). Traitement de la maladie de Dupuytren: 'Dr, quelle est cette dureté sur la paume? (J Hand Surg 2002;27A:385–390. To ensure that this method has power, we selected a positive control by repeating this analysis for a Lactase-associated SNP – rs4988235 in MCM6. He commented on the fact that ‘It is surprising that no earlier reference to this condition has been found in the Scandinavian literature’. What is the natural course of the disorder with no treatment? Cette pathologie touche notamment les hommes âgés de plus de 40 ans et également les diabétiques. Une prédisposition héréditaire est souvent retrouvée. The ‘Viking Disease’ The frequency of Dupuytren’s disease is high in many northern European countries where the Vikings settled and thus it is often nicknamed ‘The Viking Disease’. ,{i:'table2-1753193419882851',type:'table-wrap',g:[{m:'10.1177_1753193419882851-table2.gif',l:'10.1177_1753193419882851-table2.jpeg',size:'102 KB'}]} (b) Lactase-associated SNP rs4988235 shows a highly significant decrease in local haplotype sharing. Next, to assess for localized population structure at the DD-associated loci in the PoBI dataset, we used chromosome painting, comparing the frequency of haplotypes most recently shared within population groups to that between population groups (Lawson et al., 2012). Briefly, the BSSH-GODD study included a total of 7912 cases of DD and 12,937 population-based controls. By continuing to browse Lore has it that they spread it throughout northern Europe. If DD were of Norse origin, we would expect that cases would have a higher average total FST than controls. Six gènes en rapport avec la maladie ont été mis en évidence. Affections associées. La maladie de Dupuytren (également connue sous le nom de contracture de Dupuytren) est un état bénin de la peau caractérisée par la surcroissance des myofibroblasts The medical terminology used for this kind of a hand deformity is Dupuytren's contracture. Pour des raisons mal connues, ces tissus deviennent épais, se pelotonnent d’abord en boule (les nodules) ce qui entraîne des plis dans la paume ou les doigts. Tradition has it that the disease originated with the Vikings, who spread it throughout Northern Europe and beyond as they traveled and intermarried. Les fibres longitudinales prennent leur origine au nive au du tendon long palmaire ou, si ce tendon est absent, au niveau des fibres de l aponévrose antébrac hiale. In many cases it is believed to be associated with other medical conditions, although the evidence for such associations is not always clear. English new terms dictionary; Interpretations; Translations; Books; English new terms dictionary  Dupuytren's contracture. Other phenotypes, such as educational attainment, show strong associations with geography on this scale (Timpson et al., 2018). the site you are agreeing to our use of cookies. http://www.creativecommons.org/licenses/by/4.0/, https://us.sagepub.com/en-us/nam/open-access-at-sage, https://www.hsph.harvard.edu/alkes-price/software/, Common variants of the ALDH2 and DHDH genes and the risk of Dupuytren’s disease, Radiotherapy in Dupuytren’s disease: a systematic review of the evidence, Egawa T, Senuri S, Horiki A, Egawa M. Epidemiology of the Oriental patient. L'origine de cette maladie est inconnue. Although its management is undertaken by hand surgeons, it is commonly seen by other doctors as an incidental finding. Elle est liée à un épaississement de l’aponévrose palmaire. Townley, WA, Baker, R, Sheppard, N, Grobbelaar, AO. We then aggregated these scores across the 35 population labels to investigate possible geographical structure associated with known regions of high Norse ancestry, such as the Highlands of Scotland. Le traitement classique était chirurgical, … (c) Dupuytren’s genetic risk scores are not associated with geography. We found no evidence for an excess of Norse ancestry informative markers in our cases and the total FST of disease-associated SNPs was not in the top 5% of 10,000 randomly permuted SNP groups of the same size. Dupuytren's disease: what dermatologists need to know. La maladie de Dupuytren ou contracture de Dupuytren est une fibrose rétractile de l'aponévrose palmaire (une membrane située entre les tendons fléchisseurs et la peau). Enjoy the videos and music you love, upload original content, and share it all with friends, family, and the world on YouTube. Compared with 500 random samples of 21 SNPs taken from across the genome, the DD-associated SNPs do not show an increase in within-population structure (p = 0.072, Figure 2(a)), which would have been expected had DD been associated with Norse ancestry. If DD had been disseminated around Europe by the Norsemen, mention of it in one of these sources would be expected. A nominal threshold of significance of 0.05 was set, with the hypothesis that if DD is associated with Norse ancestry, the total FST of the DD-associated SNP set would be in the top 5% of permuted sets. The e-mail addresses that you supply to use this service will not be used for any other purpose without your consent. Pour des raisons mal connues, ces tissus deviennent épais, se pelotonnent d’abord en boule (les nodules) ce qui entraîne des plis dans la paume ou les doigts. Fiche de conseils Dupuytren. If you have the appropriate software installed, you can download article citation data to the citation manager of your choice. La Dystonie . The first nickname comes from the belief that the condition originated among the Vikings (inhabitants in Scandinavian countries: Denmark, Norway, and Sweden). Optimising recruitment to the HAND-1 RCT feasibility study: integration of the QuinteT Recruitment Intervention (QRI). La maladie de Dupuytren est une maladie évolutive, dont la vitesse d’évolution peut aller de quelques mois à plusieurs années. For five credible sets, there was no representative SNP in the PoBI dataset (lead SNPs: rs117402009, rs2472141, rs1042704, rs61982174, rs34088184), meaning there were 21 DD-associated SNPs remaining for analysis. La contracture de Dupuytren est un état graduel qui influence les doigts et les mains, entraînant au moins un doigt, et probablement plusieurs, à courber vers la paume de la main. For each analysis, FST was calculated between three comparator groups: Orkney vs Wales, Orkney vs South East, and Orkney vs combined Wales and South East. See Table 1 for an explanation of the terms used in this study. ... L’origine de cette maladie est encore inconnue, elle peut être d’origine génétique et pouvant atteindre plusieurs membres d’une famille. Elle touche les aponévroses, c’est à dire les enveloppes fibreuses situées entre la peau et les tendons fléchisseurs de la main. History of Dupuytren's disease Early History of Dupuytren’s Disease and Surgical Treatments. Figure 1. It is defined by Dorland as shortening, thickening, and fibrosis of the palmar fascia producing a flexion deformity of a finger. Does Dupuytren by itself affect the risk of having other conditions? Fiche Canal Carpien - Institut de la main. Bien que cela ne soit pas totalement certain, cette maladie c’est diffusée surtout en Europe lors des invasions Viking, elle peut prendre des formes variables touchant les mains, les pieds (maladie de Ledderhose) et la verge (maladie de Lapeyronie). Bien que cela ne soit pas totalement certain, cette maladie c’est diffusée surtout en Europe lors des invasions Viking, elle peut prendre des formes variables touchant les mains, les pieds (maladie de Ledderhose) et la verge (maladie de Lapeyronie). We hypothesized that if DD was caused in individuals by having Norse ancestry at these loci, then we would expect that they have an excess amount of local structure, relative to the genome as a whole. Finally, chromosome painting was used to see whether Dupuytren’s disease-associated single nucleotide polymorphisms are geographically structured. Dupuytren disease has been referred to as a Viking or Celtic disease, but existed in Europe earlier than the Viking Age8345270 and originated much earlier in prehistory 12015711. He also makes reference to both the ‘fragmentary nature of the record which has survived’ and the fact that life expectancy in previous centuries was much lower than the median age of onset of DD; these are both pertinent points that reveal the weakness of the historical case. Dupuytren's disease: a legacy of the north? Sharing links are not available for this article. Download Citation | On Nov 1, 2001, Adrian E. Flatt published The Vikings and Baron Dupuytren's Disease | Find, read and cite all the research you need on ResearchGate

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